Blocking the inflammatory cascade from within
SYK is a protein kinase that relays immune receptor signaling within a cell. It transmits signals from a variety of cell surface receptors and sends signals throughout a cell in order to trigger an immune response if needed.
SYK is the critical starting point in the activation of the inflammatory/immune cascade. Inhibition of the SYK can cause a broad anti-inflammatory effect.
How it works
The SYK signaling pathway is a key activator of multiple inflammatory and immune cell types
1. B cells
B cell activation and differentiation to antibody-secreting plasma cells
2. Effector cell
Effector cell recruitment to sites of immune complex deposition and subsequent immune activation
3. Integrin
Integrin mediate leukocyte trafficking and extravasation from blood vessels into tissue.
Controlling the critical starting point in the immune cascade
IPAC is putting this technology into action
IPAC is using SYK inhabitation to block multiple kinase signaling pathways downstream that cause inflammation and irritation in the eye. Very potent and selective SYK tyrosine kinase inhibitors have the potential to act as a broad-spectrum anti-inflammatory agent.