Dry eye disease (DED) is a chronic inflammatory condition affecting 26 million patients in Japan and South Korea.
IC 265 is being developed with the ability to significantly improve both the safety and efficacy of existing DED therapies.
In a Phase 2 conjunctival allergy challenge study, IC 265 demonstrated the following:
Takes 1 to 4 hours to reduce physiological responses
Had no adverse effects reported relating to discomfort
Was effective in reducing redness when dosed 8 hours prior to administration of allergy challenge
Was effective in reducing inflammation demonstrated by confocal microscopy
IPAC’s R&D in action
IC 265 uses our SYK kinase inhibitor that is able to block multiple downstream signaling pathways leading to different ophthalmic ailments, including dry eye.
Scientific and clinical validation
Completed Phase 2 in Conjunctival Allergen Challenge (CAC) model as proof of concept (POC) for ocular surface inflammation
Positive POC for ocular surface activity in reducing redness and demonstrated anti-inflammatory effect
IC 265 concentrations were found well tolerated in the Phase 2 study
Manufacturing clinical supplies for Good Manufacturing Practice (GMP)
Open Investigational New Drug (IND) application with US FDA
Planned Phase 2 parallel-group study in dry eye patients
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for acute pain associated with ocular neuropathic pain and dry eye; for post-surgical ocular pain management
email: [email protected]
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